Rongshi Li
University of Nebraska Medical Center, USA
Title: Fragment-based and natural product-derived antibiotics against ESKAPE pathogens
Biography
Biography: Rongshi Li
Abstract
Antibiotic drug resistance is a major threat to human health in the US and throughout the world. The infectious disease society of America has classifi ed “ESKAPE” (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.) pathogens as those able to escape the biocidal action of antibiotics. Natural products, their derivatives, metabolites, and mimics account for more than half of the new chemical entities for antiinfective drugs. Marine natural products have contributed to eight drugs or cosmeceuticals that were approved by the US Food and Drug Administration and European Medicines Agency. Fragment-based and natural product-based derivatives are powerful for drug design and discovery. Th is talk will discuss the design, synthesis, and structure-activity-relationships of natural product fragments and their derivatives for the development as potential antibiotics.