Antibiotics

Biography

Biography: Jayanta Haldar

Abstract

Multi-drug resistant Gram-positive bacteria like vancomycin resistant Enterococci (VRE) and Staphylococci (VISA and VRSA); as well as pan-drug resistant New Delhi metallo-β-lactamase-1 (NDM-1) producing Gram-negative bacteria have become a threat to the global public health. The perennial persistence of bacterial resistance, calls for urgent need to develop more potent drugs having new mode of action, which would make bacterial resistance difficult to develop. Recently, we have developed novel vancomycin analogues, which could not only overcome, acquired resistance against VRE, VISA and VRSA but also took care of the inherent vancomycin resistance towards Gram-negative bacteria. Unlike vancomycin, these vancomycin analogues showed the ability to stop the development of bacterial resistance due to incorporation of novel membrane disrupting mechanism. I will also present another strategy where the membrane-active molecules were found to re-sensitize the tetracycline antibiotics to colistin-resistant NDM-1 producing Gram-negative clinical isolates. It was observed that the membrane activity of the molecules provided a backdoor entry to the otherwise excluded antibiotics due to efflux pumps