John James Stewart Cadwell
FiberCell Systems Inc., USA
Title: The hollow fiber infection model for antimicrobial pharmacodynamics and pharmacokinetics
Biography
Biography: John James Stewart Cadwell
Abstract
The recent introduction of the hollow fiber infection model represents an important advancement in the field of in vitro toxicology. Many toxicologists believe in vitro testing methods are a useful, time and cost effective tool for drug discovery but it is generally accepted that many of the available tests are not effective for examining the effects of both time and concentration, and do not closely mimic human kinetics. This is because they do not properly take into account pharmacodynamic actions (what a drug does to the body) and pharmacokinetic actions (what a body does to the drug). With the use of hollow fiber bioreactor cartridge this has now changed. The hollow fiber infection model is a useful addition to standard in vitro toxicology methods as it mimics changes in drug concentration over time, as they would occur in humans. The hollow fiber infection can mimic precisely human bioavailability, study meaningful numbers of organisms to reveal emerging resistance, mimic both adsorption and elimination curves, define total kill in a closed, biosafe system. The clinical utility of the HFIM has been demonstrated and is now endorsed by the EMA. An overview of historic pk/pd models is presented and the utility of the system as it relates to antibiotics and other drugs are discussed.
