GENETICS OF ANTIBIOTIC RESISTANCE

Acquired bacterial antibiotic resistance can result from the mutation of normal cellular genes, the acquisition of foreign resistance genes, or a combination of these two mechanisms. The most common resistance mechanisms employed by bacteria include enzymatic degradation or alteration of the antimicrobial, mutation in the antimicrobial target site, decreased cell wall permeability to antimicrobials, and active efflux of the antimicrobial across the cell membrane. The spread of mobile genetic elements such as plasmids, transposons, and integrons has greatly contributed to the rapid dissemination of antimicrobial resistance among several bacterial genera of human and veterinary importance.

  • Antibiotic resistance genes
  • Horizontal genetic transfers
  • Multidrug-Resistant Genes
  • Resistance-nodulation-division
  • β-lactamases

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